I saw this on TV Tropes's Wild Mass Guessing page for the show. There is speculation that both Twilight Sparkle and Fluttershy have Asperger's Disorder. They cited the following examples: Twilight Sparkle: has severe OCD. Best example is in "Lesson Zero", but we also see that she consistently keeps schedules. As a person with Asperger's, I can certainly confess I do this all the time. has difficulty reading other ponies' emotions and misinterprets slang. (in "Look Before You Sleep", there's a scene where she, Applejack, and Rarity are playing a guessing game with Twilight. When Applejack asks if they are hot are cold, Twilight takes it literally and asks if she needs to change the room temperature. Is socially awkward. her high levels of intelligence her refusal to believe in that which cannot be analyzed. (Pinkie sense, anyone?) Fluttershy's symptoms: She's also socially awkward. Notice that she'd rather spend time with animals than ponies. Her inability to express emotions, particularly assertiveness. General naivete. (the "I'd like to be a tree" line) She's also had trouble interpreting social cues with others, particularly with Rainbow Dash. This may explain her inability to be corrupted by Discord. She clearly doesn't understand that the others may have opinions about her cowardice. So, what do you folks think. Are these claims valid? I do know that I read somewhere that Lauren Faust wanted to give Twilight Asperger's, but Hasbro refused to let her because they thought children would have difficulty comprehending it. (but then, Arthur dealt with it once)