I bet the could use a Colt 45 pretty well ... I have no real insight to contribute... I'll be going now.. ... Well maybe a little. I figure the unicorn ponies are pretty good at using magic, which can do some pretty extensive damage. Pegusus are well adept at flying, which could be a tactical advantage. And earth ponies are often laborers in some way, so they would be fairly strong (AKA Applejack). Plus from what we've seen i nthe show, no one is really willing to kill their opponent, so there would be no need for knives or anything... I suppose if we had a grimdark story, weapons and death would be around, but for everyday roleplaying, i dont think it would be necessary...